In terms of unheard shows, I can't think of much (although I DO remember having seen a bit of the
Noozles--probably a video ad or something).
I liked
Pepper Ann back when it was on air, and I watch
Kappa Mikey from time to time. But in terms of anime unheard of, I've seen a few episodes of
Saru Getchu: On Air.
Saru Getchu is based on a game series Westerners may know as Ape Escape, and the show features several characters from the franchise, including Kakeru (Spike), from the first AE game, as the main character, Specter, appearing in all of the games so far, as the main antagonist; even the Pipotron Brothers, their debut in Pumped & Primed, have their roles as recurring "baddies".
Admittedly, I had seen these ten-minute episodes without knowing much of what they're saying, but by watching the action and skipping the real chatty scenes, I manage to get a little bit of enjoyment.
Again, I don't believe I have seen enough obscure TV shows/cartoons to discuss deeply in this thread, but I've never heard anyone talk about USA Network's
Psyche or *gulp* Playhouse Disney's
Handy Manny--both of which I enjoy.