What's funny is I think WatchMojo, or one of those YouTube channels did a video about poor casting choices, and offered up Rosie O'Donnel as Betty Rubble, because, "Betty Rubble is one of those cartoon characters that men love to fantasize about. Rosie O'Donnel is not."
So that seems to confirm that Rosie O'Donnel is, in fact, a cartoon. Now, if we can only get a confirmation about Wayne Knight. . . .