Now, to get personal. I was a bisexual teenager going to a very conservative high school when W&G was in its heyday, and don't you think I would have given anything to have as kind and wonderful a best friend on my side as Grace? I'm not going to pretend that it was God's gift to TV (admittedly, Season Five onward was pure crap), but it meant a lot to me and by insulting W&G, you not only insult me but you insult all of its fans who have a sexual orientation other than straight.
Will and Grace isn't a annoying show because the characters are gay. Will and Grace is a terrible show because it's an annoying show with annoying, obnoxious loud characters. If they made a show about someone squeaking Styrofoam for a half hour, it would be less grating. And this is coming from someone who cowers in pain when someone opens a box.
I get that the show resonated with you on some level. If you like it, that's cool. I don't like how loud and fast everything has to be, I don't like Sean Hayes's screeching (his best work is when he plays brains in jars... seriously. He played that exact role twice), and his Jar Jar Binks like antics. And I especially hate how the producers keep trying to make the same show with the same tired gay stereotypes.
To give you an idea, I'm not too fond of FRIENDS either, but I respect the cultural impact it had. It did have it's fair share of laughs every so often... and hey Melodia from Silverhawks was Janice. But (being forced to watch it, so that kinda taints something for me) I just don't get Will and Grace's popularity for anything else other than having gay characters in it. The proof? That was the ONLY successful sitcom those guys ever had.
EDIT: That's not to say I find the show inherently the worst. I mean, I dislike it, but the thread is about annoying shows, not worst shows. I can think of things much worse than this show, but they aren't so much annoying as terrible. I'll give W&G this... it's not half as terrible as According to Jim, Hope and Faith, or that thing where Damon Wayans was unfunny.