It seems there's a good mother/daughter Pre-Sesame Beginnings concept that could have came out of this. This may not be an impressive sketch on a comedy level, but there's something about the interaction of a nurturing mother figure trying to calmly deal with a rambunctious monster toddler. Some of the humor in this seems geared for the parents watching with their younger ones, especially how Deena started screaming for her bottle as soon as both started to finally go to sleep. I get an "ammiright?" from the writers here.Deena and Pearl, at least from this segment, are a pretty meh pair of characters. But I'll have to see how the other segs are to judge them as a whole.
That said, I do like the comparison to Leslie Mostly. I still don't get that sketch series at all. Deena and Pearl at least may have a subtle connection to parents saying "this is your kid, you've dealt with this, you continue to deal with this, you can see humor in this situation." Leslie Mostly seems like a not that great idea. It's essentially trying to do Kermit the Frog: Ace Reporter's job without what made any of that funny. Leslie was too unflappable and uninteresting (at least in that one segment that finally surfaced).