What they do on SS is "skits," and not very many of them. On a Sitcom it would be an episode directed solely for a particular character and a particular story without interruptions from animated bits, etc. That's how it would be different.
Unfortunately, my discussion actually takes away from the thread's main topic which is about an animated series. I've muffined!
I liked the WB animation in Follow that Bird. I thought it was very neat and I wouldn't mind seeing more of that, especially on SS where they could take the characters a little further than with puppetry--but, with green-screen technology is it even anything that they need to bother with?
I once got a letter from Disney when I mentioned to them to have HA! (that's how long ago it was) create puppets of Mickey and the Gang and do some specials like that. they wrote back and said it wasn't in the integrity of the characters to produce a show with them as puppets. Therefore, it may not be within the integrity of taking puppets and producing them as 'toons.
However, some cool SS comic strips might be neat--or comics.