Whoever's in charge of making Muppet VG's hasn't done a great job so far, no offense, so I think they should put us in charge, as we seem to have much better ideas. I mean, it's unbelievable how badly they've dropped the ball thus far, and with some things (e.g. many of the current post-Flashpoint DC comics, for any comic book fans on the board, the Star Wars prequels), I think you could make a solid argument that the fans truly could have done a better job than the people in charge. So I say c'mon, just for once, let the fans have an actual say in the things they love so much.
Anyway, to put another idea out their, I'd be all for a Pigs in Space game. It wouldn't be just a skit like on TMS, it would actually be Link, Piggy, and Strangepork in their own adventure. Part of it would involve navigating the Swinetrek through space and fighting hostile ships, part of it would involve hostile entities and problems aboard the Swinetrek itself, like the majority of Pigs in Space skits, and part of it would involve Link, Piggy, and Strangepork exploring the planet Koozebane. It could definitely be multiplayer, with players taking on the role of Link, Piggy, or Strangepork, and it could definitely have appearances from other Muppets. For example, there could be a mission where players have to safely escort roving reporter Kermit the Frog through the dangers of Koozebane and back to the Swinetrek, and another mission where players must fight Dearth Nadir, Gonzo's Darth Vader parody from episodes 402 and 417 of TMS.