I don't mind the Simpsons being on forever, much like Sesame Street or Saturday Night Live. Family Guy... ehhh.. I still like and watch the show, but I agree with Seth who wanted to actually stop the series a while ago. Then again, since no one went to see "A Million Ways to Die in the West," (and a darn shame too, because it was pretty good. Not quite Ted, but still miles ahead of his show), I doubt that he'll see much of a film career after Ted 2 (unless that;s successful... then and only then Ted 3).
Bob's I wouldn't say was destined to have much of a shelf life, but if Fox decides to cancel it because of its poor time slot, the show should be renewed for adult swim, where it's better off anyway.