For a handful of the kids, as well as adults:
Arthur - Moved to England and became actor Daniel Radcliffe.
D.W. - Moved to the Lower East Side of New York in order to help troubled youth. Let's just say she put more fear in them than they had ever seen.
Buster - Became a cast member on Saturday Night Live.
Francine - Trained for the Olympics, and almost made it through, but was once again defeated by Jenna. She disappeared afterwards.
Muffy - Formed OWN with Oprah Winfrey.
Brain - Became the first bear President.
Binky - Became a professional dancer. Played the Joker in "Batman: The Ballet"
Sue Ellen - Became a secret agent.
Fern - Became a best-selling authoress.
George - Worked as Sherri Lewis' assistant. Later formed his own entertainment group with Wally.
Wally - Became an internet meme.
Dave Read - Opened his own bakery.
Jane Read- Continued working as an accountant. Currently retired.
Bitzi Baxter - With the popularity of newspapers dwindling, she briefly went into financial trouble. Eventually became her son's manager.
Bo Baxter - Became a travel agent. Regularly skyps with Buster.
Miss Blank - After losing her job as a substitue teacher (she never showed up for the job) completely vanished off the face of the earth.
The Tibbles - Landed in and out of jail for different reasons. Later 'taught' by D.W.
Emily - Got her own reality show.
Pal - Became a movie star.
Kate - Spent many years in therapy after trying to convince people that she could talk to animals.
Mr. Ratburn - Eventually retired and moved to Cake City, Florida.
Mr. Haney - Currently resides in a retirement home.
Mr. Morris - Also in a retirement home.
Thora Read - Lived to be 100.
Mrs. McGrady - Er... maybe I shouldn't go there.
Rattles - Became a nightclub owner. Has severe ties with the Mafia.
Molly - Became a camp counselor.
Prunella - Went balmy.
Nadine - Continues to hang out with D.W. Constantly haunts Arthur.