Actually, I wouldn't mind a sitcom ... so long as they aren't putting on a show, otherwise it'd just be the Muppet Show ... why not call it that?
Hm ... what do I wanna see...?
Since Disney-owned Dinosaurs never got a chance (well, and they hadn't been invented yet) to mingle in the Family Christmas ... I'd like to see them incorporated somehow. If they did a sitcom, I wouldn't the Muppets to do parodies of tv shows on EVERY episode, but a few nods here and there would be nice. Do Land of the Lost or something ... and you can fit the Sinclairs in as guest stars. *squeals* Have a Farscape parody ... if Stargate gets to do one, so should the Muppets, dang it! I'd like to see some mocking of Disney shows as well. For the actual plot of the series, I'd like it to be more like Roseanne or something (hang on, don't run away yet) ... in other words, it would focus on the characters and not need some major story arc unless they wanted to. The Muppets.com stuff is very amusing and I think a more character-based show would fit better at the moment, since they've been just merchandise for years until recently. Make newer generations SEE that these are characters.
On a sitcom....
1. I've never seen Muppets from Space (want to), but why are they all in one house? Shouldn't AT LEAST Kermit have his own "pad" on SS? Yeah, they probably wouldn't mention it anymore, but it strains credibility that EVERY SINGLE MUPPET can't afford his/her/its own housing SOMEWHERE. I'd like the main set to be an apartment complex or something. Don't tell me it would be too costly to redress the same room over and over.
2. References to the movies would be nice. They had a hit on Broadway ... why the heck is the Muppet Theater always broke?
3. TV parodies would be due to Bunsen and Beaker experimenting with some weird electronic gadget.
4. The Electric Mayhem would have their own file-sharing service and youtube/myspace stuff that would actually be in reality for all of us to see.
5. A soap-opera parody with Scooter finding out he has an evil twin sister. *dies laughing*