No, it's actually Patrick Stewart! Which makes it that much more awesome. He plays Stan's boss on American Dad so he probably recorded this cameo at the same time.
I have volumes 3, 4, and 5 (the one that just came out). I buy them at Costco for $20 each. They are worth so much more than that but it's great that we can get them cheap, eh? The next one I'd like to buy is volume 2, because I love the episode when Brian becomes a police dog. Also, I've only seen clips of Road to Europe and I want to see it from start to finish.
Edit: Since we're on the subject, there's also a cutaway of the bridge of Star Trek where Captain Picard (played by Stewart of course) is laughing about Commander Worf's face.
http://youtube.com/watch?v=eKW97uEF5vA
Enjoy, Prawnie!