Finally caught the first episode and I'd say it met my expectations. I wasn't extremely surprised by it, nor was I disappointed. I had high standards for this show and they were met exactly. I mean, the first episode was very piloty, but not excessively so. I like how his female friend pretty much is that comfortable with Milo's bad luck that she was able to bet on him the way she did, yet was a little bit concerned about her grade point average when they had to build the egg cradle. Overall, I get a Phineas and Ferb (minus Perry and Doof) meets Eek the Cat vibe.
I feel this show definitely has potential, and hopefully they can get a lot of mileage of Milo being unlucky without it getting repetitive relatively early. Sure, Phineas and Ferb had a formula to it, but it played with it and parodied it halfway through. I'm sure if they get stuck on this series, they can pull it out with a sarcastic nod to it's themes.