The show had some brilliant plans for Brain and it did have it's fair share of actually funny bits. What really bugs me isn't so much Elmyra, but their portrayal of Bill Nye the Science Guy as an effeminate moron was kinda Didn't do the Research to the point of insulting. The problem with the show was that there actually were pretty good concepts that went nowhere, a failure to connect Elmyra to Tiny Toons in any way, I guess that they didn't want to make Furball Elmyra's cat because they wanted something more sinister... and let's face it, Furball was so sympathetic that it backfired on the Tiny Toons writers. Check out any one of the video games... they actually make Sweety the villain. But replacing all the other characters killed some potential. Imagine Monty in the show instead of Rudy. Not to mention the secret organization trying to find Brain they used in... like one episode.
But I did love the episode where Brain has a show on an OBVIOUS parody of Kid's WB, including the "stars" or their "Sitcoms" introducing shows on the commercial bumpers.
it's not so much a bad show as a total waste.